Welcome!

This website is provided so you can find out about my research work. You will find my biography, miscellaneous photos, my worldwide coraborations, links to very important sites, and my contact information.

LABORATORY AIM:
My research laboratory focuses on understanding the molecular mechanisms involved in the pathogenesis of neurodegenerative disorders. This includes Alzheimer’s disease (AD), ischemia and essential tremor. The laboratory has special expertise in AD and calcium signaling. My team investigates the calcium hypothesis in synaptic amyloid-beta protein (Abeta) buildup and tau  phosphorylation. Abeta and p-tau are the major AD pathological characteristics.

Using post-mortem human brain regions affected by Amyloid-beta and different mouse models of AD, we are studying specific proteins involved in the calciumopathy of AD pathology in order to identify key player that could yield insights into new AD therapies.

S. Sokolow, S. H. Luu, C.A. Miller, H.V. Vinters, W. W Poon, and K..H. Gylys. Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer’s disease cortex (2011). Neurobiol of disease, in press.

J. M. Ringman, H. Schulman,C. Becker, T. Jones, Y. Bai, F. Immermann, G. Cole, S. Sokolow, K. Gylys, D.H. Geschwind,  J.L. Cummings, H.I. Wan. Proteomic Changes in Cerebrospinal Fluid of Pre-Symptomatic and Affected Persons Carrying Familial Alzheimer's Disease Mutations (2011). Arch Neurol, in press.

S. Sokolow, K.M. Henkins, T. Bilousova, C.A. Miller, H.V. Vinters, W. W Poon, G.M. Cole, K..H. Gylys. AD synapses contain Ab monomer and multiple soluble oligomers, including a 56 kDa assembly (2011). Neurobiol of aging, doi:10.1016/j.neurobiolaging.2011.05.011

E. Nguidjoe*, S. Sokolow*, S. Bigabwa, N. Pachera, F. Allagnat, J. M. Vanderwinden, A. Sener, M. Manto, M. Depreter, J. Mast, G. Joanny, E. Montanya, J. Rahier, A. K. Cardozo, D. L. Eizirik, S. Schurmans and A. Herchuelz. Partial null mutation of Na/Ca exchanger 1 increases glucose-induced first phase insulin release, beta-cell proliferation and beta-cell-mass (2011). Diabetes. 60(8):2076-85. * Authors contributing equally to the investigation.

P. Molinaro, D. Viggiano, R Nisticò, A. Secondo, F. Boscia, A. Pannaccione, A. Scorziello, B. Mehdawy, S. Sokolow, A. Herchuelz, G. Di Renzo and L. Annunziato. NCX3 knock-out mice display an impairment in hippocampal LTP and spatial learning and memory (2011). J Neurosc. 31(20):7312-21.

S. Sokolow, S. H. Luu, A. J. Headley, A. Y. Hanson, T. Kim, C. A. Miller, H. V. Vinters, K. H. Gylys. High levels of synaptosomal Na+-Ca2+ exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease (2011). Cell calcium. 49(4):208-16.

J. L. Cross, B. P. Meloni, A. J. Baker, S._Sokolow, A. Herchuelz, S. Schumans, N. W. Knuckey, Neuronal injury in NCX3 knockout mice following permanent focal cerebral ischemia and in NCX3 knockout cortical neuronal cultures following oxygen-glucose deprivation and glutamate exposure. J. Exp. Stroke & Translational Medicine, 2(1), 2009

A worldwide multicenter comparison of assays for CSF biomarkers in Alzheimer disease. N. A. Verwey, W. M. Van der Flier, K. Blennow, C. Clark, S._Sokolow, P. P. De Deyn, D. Galasko, H.J. Hampel, T. Hartmann, E. Kapaki, L. Lannfelt, P. D. Mehta, L. Parnetti, A. Petzold, T. Pirttila, L. Saleh, A. Skinningsrud, J. Van Swieten, M. M. Verbeek, J. Wiltfang, S. G. Younkin, P. Scheltens, and R. A. Blankenstein. Ann Clin Biochem: 46 (3): 235-40, 2009.

J. M. Ringman, S. G. Younkin, D. Pratico, W. Seltzer, G. M. Cole, D. H. Geschwind, Y. Rodriguez, B. Schaffer, J. Fein, S. Sokolow, E. R. Rosario, K. H. Gylys, A. Varpetian, L. D. Medina, J.L. Cummings. Biochemical Markers in Persons with Pre-Clinical Familial Alzheimer's Disease. Neurology. 8;71(2):85-92, 2008.

A. Fein, S._Sokolow, C. A. Miller, H. V. Vinters, F. Yang, G. M. Cole, K. H. Gylys. Co-localization of amyloid beta and tau pathology in Alzheimer’s disease synaptosomes. Am. J. Pathol. 172(6):1683-92, 2008.

M. Wehling-Henricks*, S._Sokolow*, J. J. Lee, K. H. Myung, A. Villalta and J. G. Tidball. Major basic protein-1 promotes fibrosis of dystrophic muscle and attenuates the cellular immune response in muscular dystrophy. Hum. Mol. Genet. 17(15):2280-92, 2008.* Authors contributing equally to the investigation.

P. Molinaro, O. Cuomo, G. Pignataro, F. Boscia, R. Sirabella, A. Pannaccione, A. Secondo, A. Scorziello, A. Adornetto, R. Gala, S._Sokolow, A. Herchuelz, S. Schurmans, G. Di Renzo, L. Annunziato. Targeted Disruption of Na+/Ca2+ Exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage.J. Neurosci. 28(5), 1179-84, 2008.

G. J. Jeffs, B. P. Meloni, S._Sokolow, A. Herschuelz, S. Schurmans and N. W. Knuckey. NCX3 knockout mice exhibit increased hippocampal CA1 and CA2 neuronal damage compared to wild-type mice following global cerebral ischemia. Exp Neurol. 210 (1), 268-273, 2008.

M. Philippeau, M. Manto, S._Sokolow, M. A. Laute J. P Brion, M. Pandolfo and R. Pochet Recent advances in transgenic models of ALS - Electrophysiological, morphological and neurochemical characterization of hSOD-1 G93A transgenic rats.Recent Research in Developmental Physiology, 3:13-31, 2005.

S. Sokolow, M. Manto, P. Gailly, J. Molgo, C. Vandebrouck, J. M. Vanderwinden, A. Herchuelz and S. Schurmans. Impaired neuromuscular transmission and skeletal muscle fiber necrosis in mice lacking Na/Ca exchanger 3. J.Clin.Invest 113 (2), 265-273, 2004.

F. Rogister, D. Laeckman, PO. Plasman, F. Van Eylen, M. Ghyoot, C. Maggetto, S._Sokolow, J-F. Liegeois, J. Geczy, B Masereel, J. Delarge and A. Herchuelz. Novel inhibitors of the sodium-calcium exchanger: benzene ring analogues of N-guanidino substitued amiloride derivatives. Eur. J. Med. Chem., 36 (7-8), 597-614, 2001.

S._Sokolow and A. Herchuelz. Hypnotiques-Anxiolytiques. Syllabus de Pharmacologie Speciale, 1ère édition, Presses Universitaires de Bruxelles, 2001 - 2002. (Hypnotics-Anxiolytics. Handbook of Special Pharmacology, 1st Edition, Press of the University of Brussels, 2001 – 2002).

FUNDED PROPOSALS (ACTIVE):

New Investigator Research Grant   
Agency: Alzheimer’s Association
Sokolow (PI) July. 2011 –2013
The proposal entitled:” Biochemical & functional analyses of the Na+/Ca2+ exchanger in AD pathology”

Mary S. Easton Center for Alzheimer's Research at UCLA - pilot grant                                           
Agency: NIA
Sokolow (PI) Apr. 2011 –2012
The proposal entitled “Biochemical & functional analyses of the Na+/Ca2+ exchanger in AD nerve terminals”

 

RECENT AWARDS:

UCLA Faculty Diversity and Development. Faculty Career Development Award.                                               Fall 2011

14th International Conference on Alzheimer’s Disease (ICAD). Travel Fellowship, Paris, France.            
July 16-21, 2011